CBP/p300-IN-19 (hydrochloride)
CBP/p300-IN-19 hydrochloride is a potent and selective p300/CBP HAT inhibitor with IC50s of 1.4, 2.2, >100, >100 μM for p300-HAT, CBP-HAT, PCAF, Myst3, respectively. CBP/p300-IN-19 hydrochloride shows antitumor activity[1].
Product Specifications
CAS Number
[2592638-14-5]
UNSPSC
12352005
Target
Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cbp-p300-in-19-hydrochloride.html
Concentration
10mM
Purity
99.00
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
[H]Cl.C1(C2=CC=C(C3=COC=C3)C=C2)=NC=C(OCC4CCNCC4)N=C1C5=CC=C(C6=COC=C6)C=C5
Molecular Formula
C30H28ClN3O3
Molecular Weight
514.01
References & Citations
[1]Nie S, et al. Structure-activity relationship and antitumor activity of 1,4-pyrazine-containing inhibitors of histone acetyltransferases P300/CBP. Eur J Med Chem. 2022 Jul 5;237:114407.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CBP/p300; GCN5/PCAF
Available Sizes
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