AZD2932
AZD2932 is a potent and multi-targeted kinase inhibitor VEGFR2, PDGFβ, Flt-3 and c-Kit with IC50s of 8, 4, 7 and 9 nM in cell assay, respectively.
Product Specifications
CAS Number
883986-34-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
C-Kit; FLT3; PDGFR; VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AZD2932.html
Purity
98.16
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
O=C(NC1=CN(C(C)C)N=C1)CC2=CC=C(OC3=C4C=C(OC)C(OC)=CC4=NC=N3)C=C2
Molecular Formula
C24H25N5O4
Molecular Weight
447.49
Precautions
H302, H315, H319, H335
References & Citations
[1]Plé PA, et al. Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases. Bioorg Med Chem Lett. 2012 Jan 1;22 (1) :262-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDGFRβ; VEGFR2/KDR/Flk-1
Available Sizes
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