Apalutamide-COOH
Apalutamide-COOH is a metabolite of Apalutamide. Apalutamide is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM[1].
Product Specifications
CAS Number
1332391-04-4
UNSPSC
12352005
Hazard Statement
H361, H372
Target
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/apalutamide-cooh.html
Concentration
10mM
Purity
99.76
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(O)C1=CC=C(N(C(N(C2=CC(C(F)(F)F)=C(C#N)N=C2)C3=O)=S)C43CCC4)C=C1F
Molecular Formula
C20H12F4N4O3S
Molecular Weight
464.39
Precautions
H361, H372
References & Citations
[1]Nicholas D. Smith, et al. Androgen receptor modulators and uses thereof. WO2011103202A2.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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