Sialyl-Lewis X

Sialyl-Lewis X (sLeX) is a sialylated fucosylated tetrasaccharide, an endogenous antigen. Sialyl-Lewis X is a high-affinity ligand for selectins (E-, P-, and L-selectin) [1]. Sialyl-Lewis X binds to ELAM-1 and CD62 and has the ability to inhibits CD62-mediated neutrophil recruitment to sites of inflammation[2].

Product Specifications

CAS Number

[98603-84-0]

Product Name Alternative

SLeX

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sialyl-lewis-x.html

Purity

98.56

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

OC([C@](O[C@@]([C@@H]1NC(C)=O)([H])[C@H](O)[C@H](O)CO)(C[C@@H]1O)O[C@@H]([C@H]([C@H]2CO)O)[C@H]([C@@H](O2)O[C@@]([C@H](O)CO)([H])[C@]([C@H](C=O)NC(C)=O)([H])O[C@H](O[C@H]3C)[C@H]([C@@H]([C@@H]3O)O)O)O)=O

Molecular Formula

C31H52N2O23

Molecular Weight

820.74

Precautions

H302, H315, H319, H335

References & Citations

[1]M J Polley, et al. CD62 and Endothelial Cell-Leukocyte Adhesion Molecule 1 (ELAM-1) Recognize the Same Carbohydrate Ligand, sialyl-Lewis X. Proc Natl Acad Sci U S A. 1991 Jul 15;88 (14) :6224-8.|[2]L A Lasky, et al. Selectins: Interpreters of Cell-Specific Carbohydrate Information During Inflammation. Science