BC-1382

BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction (IC50≈ 5 nM) .Anti-inflammatory activity[1].

Product Specifications

CAS Number

[1013753-99-5]

UNSPSC

12352005

Hazard Statement

H302-H312-H315-H319-H332-H335

Target

E1/E2/E3 Enzyme

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/bc-1382.html

Purity

99.53

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C1CCN(S(=O)(C2=CC=CC=C2)=O)CC1)N[C@@H](C)C(NCC3=CC=CC=C3OC)=O

Molecular Formula

C23H29N3O5S

Molecular Weight

459.56

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

References & Citations

[1]Tiffany A Coon, et al. The proinflammatory role of HECTD2 in innate immunity and experimental lung injury. Sci Transl Med. 2015 Jul 8;7 (295) :295ra109.