2'-epi-2'-O-Acetylthevetin B
Selected Variant
HY-N12140-01
Size: 1 mg
2'-epi-2'-O-Acetylthevetin B (GHSC-74) is a cardiac glycoside that can be isolated from the seeds of Cerbera manghas L. 2'-epi-2'-O-Acetylthevetin B inhibits cell viability, induces apoptosis and loss of mitochondrial membrane potential in HepG2 cells[1].
Product Specifications
CAS Number
82145-55-9
Product Name Alternative
GHSC-74
UNSPSC
12352005
Target
Apoptosis
Type
Natural Products
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/2-epi-2-o-acetylthevetin-b.html
Solubility
10 mM in DMSO
Smiles
O[C@@]12[C@@]3([H])[C@@](CC[C@@]1([C@@H](C(CO4)=CC4=O)CC2)C)([H])[C@@]5([C@](C[C@H](CC5)O[C@H]6[C@H]([C@@H]([C@H]([C@@H](O6)C)O[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O)O)O)CO[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)CO)OC)OC(C)=O)([H])CC3)C
Molecular Formula
C44H68O19
Molecular Weight
901.00
References & Citations
[1]Feng B, et al. 2'-Epi-2'-O-acetylthevetin B induces apoptosis partly via Ca (2+) -mediated mitochondrial pathway in human hepatocellular carcinoma HepG2 cells. Cell Biol Int. 2009 Sep;33 (9) :918-25.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
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