EGFR kinase inhibitor 3
EGFR kinase inhibitor 3 (compound 2) is a bivalent ATP-allosteric EGFR kinase inhibitor with IC50s of [1].
Product Specifications
CAS Number
[2922402-03-5]
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-kinase-inhibitor-3.html
Purity
99.03
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=CC(C2=C(NC(SC)=N2)C3=CC=NC(NC(C)=O)=C3)=C1)C4=C5NC(C6=C(NC5=CC=C4)C=CC=C6)=O
Molecular Formula
C31H25N7O3S
Molecular Weight
575.64
References & Citations
[1]Florian Wittlinger, et al. Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors. Commun Chem. 2024 Feb 20;7 (1) :38.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1
Available Sizes
Curated Selection
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