NQO1 substrate
NQO1 substrate acts as an efficient NQO1 substrate and may be a new option for the treatment of NQO1-overexpresssing drug-resistant NSCLC[1].
Product Specifications
CAS Number
2304503-05-5
Product Name Alternative
AM152
UNSPSC
12352005
Target
Quinone Reductase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nqo1-substrate.html
Purity
98.02
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
N#CC1=C(C#N)N=C2C(C(C3=C2C=C(F)C(F)=C3)=O)=N1
Molecular Formula
C13H2F2N4O
Molecular Weight
268.18
References & Citations
[1]Wu X, et al. Discovery of Nonquinone Substrates for NAD (P) H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small-Cell Lung Cancer. J Med Chem. 2018 Dec 27;61 (24) :11280-11297.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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