EA-B2L
Product Specifications
UNSPSC Description
EA-B2L is a potent degrader of glutathione S-transferase (GSTP), with the DC50 of 48 μM. EA-B2L is a kind of Boc2Lys-linked Ethacrynic acid (HY-B1640). EA-B2L plays an important role in cancer research[1].
Target Antigen
Glutathione S-transferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ea-b2l.html
Smiles
CCC(C(C1=C(C(Cl)=C(C=C1)OCC(NCCCCCCNC([C@H](CCCCNC(OC(C)(C)C)=O)NC(OC(C)(C)C)=O)=O)=O)Cl)=O)=C
Molecular Weight
729.73
References & Citations
[1]Hui Sun, et al. Identification of Boc2Lys-Linked Ethacrynic Acid and Its Analogues As Efficient Glutathione S-Transferase Degraders. ACS Med Chem Lett. 2024 Oct 14;15(11):1852-1859
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-169350/EA-B2L-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-169350/
Clinical Information
No Development Reported
CAS Number
1354444-72-6
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