EA-B2L

EA-B2L is a potent degrader of glutathione S-transferase (GSTP), with the DC50 of 48 μM. EA-B2L is a kind of Boc2Lys-linked Ethacrynic acid (HY-B1640) . EA-B2L plays an important role in cancer research[1].

Product Specifications

CAS Number

[1354444-72-6]

UNSPSC

12352211

Target

Glutathione S-transferase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ea-b2l.html

Smiles

CCC(C(C1=C(C(Cl)=C(C=C1)OCC(NCCCCCCNC([C@H](CCCCNC(OC(C)(C)C)=O)NC(OC(C)(C)C)=O)=O)=O)Cl)=O)=C

Molecular Formula

C35H54Cl2N4O8

Molecular Weight

729.73

References & Citations

[1]Hui Sun, et al. Identification of Boc2Lys-Linked Ethacrynic Acid and Its Analogues As Efficient Glutathione S-Transferase Degraders. ACS Med Chem Lett. 2024 Oct 14;15 (11) :1852-1859