KYP-2047

KYP-2047 is a potent and BBB-penetrating prolyl-oligopeptidase (POP) inhibitor, with an Ki value of 0.023 nM. KYP-2047 reduces glioblastoma proliferation through angiogenesis and apoptosis modulation[1][2].

Product Specifications

CAS Number

[796874-99-2]

UNSPSC

12352005

Hazard Statement

H319

Target

Apoptosis; MDM-2/p53; Prolyl Endopeptidase (PREP)

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kyp-2047.html

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N#C[C@H]1N(C([C@H]2N(C(CCCC3=CC=CC=C3)=O)CCC2)=O)CCC1

Molecular Formula

C20H25N3O2

Molecular Weight

339.43

Precautions

H319

References & Citations

[1]Jalkanen AJ, et al. Beneficial effect of prolyl oligopeptidase inhibition on spatial memory in young but not in old scopolamine-treated rats. Basic Clin Pharmacol Toxicol. 2007 Feb;100 (2) :132-8.|[2]Scuderi SA, et al. KYP-2047, an Inhibitor of Prolyl-Oligopeptidase, Reduces GlioBlastoma Proliferation through Angiogenesis and Apoptosis Modulation. Cancers (Basel) . 2021 Jul 9;13 (14) :3444.