SP-141

SP-141 is a specific inhibitor of MDM2. SP-141 promotes MDM2 auto-ubiquitination and degradation. SP-141 might be used for the research of pancreatic cancer and breast cancer cells[1].

Product Specifications

CAS Number

[1253491-42-7]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sp-141.html

Purity

99.94

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

COC1=CC2=C(NC3=C2C=CN=C3C4=C5C=CC=CC5=CC=C4)C=C1

Molecular Formula

C22H16N2O

Molecular Weight

324.38

Precautions

H315, H319, H335

References & Citations

[1]Wei Wang , et al. Identification of a New Class of MDM2 Inhibitor That Inhibits Growth of Orthotopic Pancreatic Tumors in Mice. Gastroenterology. 2014 Oct;147 (4) :893-902.e2.|[2]Wei Wang, et al. The Pyrido[b]indole MDM2 Inhibitor SP-141 Exerts Potent Therapeutic Effects in Breast Cancer Models. Nat Commun. 2014 Oct 1;5:5086.