PD168393

PD168393 is a potent, selective and cell-permeable inhibitor of EGFR tyrosine kinase and ErbB2. PD168393 irreversiblely inactivates EGF receptor (IC50=0.7 nM) and is inactive against insulin receptor, PDGFR, FGFR and PKC[1].

Product Specifications

CAS Number

[194423-15-9]

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Autophagy; EGFR

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PD168393.html

Purity

98.58

Solubility

DMSO : ≥ 30 mg/mL

Smiles

C=CC(NC1=CC2=C(NC3=CC=CC(Br)=C3)N=CN=C2C=C1)=O

Molecular Formula

C17H13BrN4O

Molecular Weight

369.22

Precautions

H302

References & Citations

[1]D W Fry, et al. Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor. Proc Natl Acad Sci U S A. 1998 Sep 29;95 (20) :12022-7.