Danegaptide Hydrochloride
Danegaptide Hydrochloride (GAP-134 Hydrochloride) is a potent, selective and orally active gap-junction modifier with an antiarrhythmic effect[1][2].
Product Specifications
CAS Number
943133-81-1
Product Name Alternative
GAP-134 (Hydrochloride) ; ZP 1609 Hydrochloride
UNSPSC
12352005
Hazard Statement
H302
Target
Gap Junction Protein
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/GAP-134-Hydrochloride.html
Concentration
10mM
Purity
99.49
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL
Smiles
O=C(N[C@H]1CN(C(CN)=O)[C@H](C(O)=O)C1)C2=CC=CC=C2.[H]Cl
Molecular Formula
C14H18ClN3O4
Molecular Weight
327.76
Precautions
H302
References & Citations
[1]John A Butera, et al. Discovery of (2S,4R) -1- (2-aminoacetyl) -4-benzamidopyrrolidine-2-carboxylic acid hydrochloride (GAP-134) 13, an orally active small molecule gap-junction modifier for the treatment of atrial fibrillation. J Med Chem. 2009 Feb 26;52 (4) :908-11.|[2]Elke De Vuyst, et al. Pharmacological modulation of connexin-formed channels in cardiac pathophysiology. Br J Pharmacol. 2011 Jun;163 (3) :469-83.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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