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Val-Cit-PAB-MMAE

Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC. Val-Cit-PAB-MMAE contains the ADCs linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE (HY-15162) . MMAE a potent mitotic inhibitor by inhibiting tubulin polymerization.

Product Specifications

CAS Number

[644981-35-1]

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Val-Cit-PAB-MMAE.html

Purity

99.98

Solubility

DMSO : ≥ 110 mg/mL

Smiles

CC[C@H](C)[C@@H]([C@@H](CC(N1[C@@H](CCC1)[C@@H]([C@@H](C)C(N[C@H](C)[C@@H](O)C2=CC=CC=C2)=O)OC)=O)OC)N(C([C@H](C(C)C)NC([C@H](C(C)C)N(C(OCC3=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)N)=O)=O)C=C3)=O)C)=O)=O)C

Molecular Formula

C58H94N10O12

Molecular Weight

1123.43

References & Citations

[1]Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16 (3), 888-897.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, stored under nitrogen)

Scientific Category

ADC Related

Clinical Information

No Development Reported

Isoform

Auristatin

Available Sizes

Curated Selection

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