AP1867
AP1867 is a synthetic FKBP12F36V-directed ligand[1].
Product Specifications
CAS Number
[195514-23-9]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
FKBP
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AP1867.html
Purity
99.27
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=CC=C(CC[C@@H](OC([C@@H]2CCCCN2C([C@H](C3=CC(OC)=C(OC)C(OC)=C3)CC)=O)=O)C4=CC=CC(OCC(O)=O)=C4)C=C1OC
Molecular Formula
C38H47NO11
Molecular Weight
693.78
Precautions
H315, H319, H335
References & Citations
[1]Nabet B, et al. The dTAG system for immediate and target-specific protein degradation. Nat Chem Biol. 2018 May;14 (5) :431-441.|[2]Koide K, et al. A synthetic library of cell-permeable molecules. J Am Chem Soc. 2001 Jan 24;123 (3) :398-408.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
FKBP12
Available Sizes
Curated Selection
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