(E) -Crotonic acid

NSC 8751 (trans-2-Butenoic acid; trans-Crotonic acid) is an unsaturated carboxylic acid compound containing α, β-unsaturated carboxylic acid groups. NSC 8751 is one of the important analogs for evaluating the safety of fragrance ingredients and is used to evaluate the toxicological properties of compounds with similar structures. When NSC 8751 is applied to local lymph nodes, a 50% concentration does not cause skin sensitization. Structural analogs of NSC 8751 have been shown to be non-genotoxic. trans-Crotonic acid can be used in the preparation of cosmetics and food additives[1][2].

Product Specifications

CAS Number

[107-93-7]

Product Name Alternative

(E) -2-Butenoic acid; trans-2-Butenoic acid; trans-Crotonic acid

UNSPSC

12352211

Hazard Statement

H318

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/nsc-8751.html

Purity

99.77

Solubility

H2O : 25 mg/mL (ultrasonic)

Smiles

C/C=C/C(O)=O

Molecular Formula

C4H6O2

Molecular Weight

86.09

Precautions

H318

References & Citations

[1]Api AM, et al. RIFM fragrance ingredient safety assessment 2-methyl-trans-2-butenoic acid, CAS Registry Number 80-59-1. Food Chem Toxicol. 2018 Sep;118 Suppl 1:S1-S7.|[2]Jasicka-Misiak I, et al. Crotonic acid as a bioactive factor in carrot seeds (Daucus carota L.) . Phytochemistry. 2005 Jun;66 (12) :1485-91.