(+) -Norfenfluramine

(+) -Norfenfluramine a major hepatic metabolite of (+) -fenfluramine, is a selective 5-HT2B receptor agonist (Ki: 11.2 nM) . (+) -Norfenfluramine potently stimulates the hydrolysis of inositol phosphates and increases intracellular Ca2+. (+) -Norfenfluramine can be used for the research of primary pulmonary hypertension and valvular heart disease[1].

Product Specifications

CAS Number

[19036-73-8]

Product Name Alternative

D-Norfenfluramine

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/plus-norfenfluramine.html

Purity

99.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C=1(C=C(C=CC1)C(F)(F)F)C[C@H](C)N

Molecular Formula

C10H12F3N

Molecular Weight

203.20

Precautions

H315, H319, H320

References & Citations

[1]Wei Ni, et al. The 5-hydroxytryptamine2A receptor is involved in (+) -norfenfluramine-induced arterial contraction and blood pressure increase in deoxycorticosterone acetate-salt hypertension. J Pharmacol Exp Ther. 2007 May;321 (2) :485-91. |[2]M Gobbi, et al. In vitro studies on the mechanism by which (+) -norfenfluramine induces serotonin and dopamine release from the vesicular storage pool. Naunyn Schmiedebergs Arch Pharmacol. 1998 Sep;358 (3) :323-7. |[3]R Invernizzi, et al. Is receptor activation involved in the mechanism by which (+) -fenfluramine and (+) -norfenfluramine deplete 5-hydroxytryptamine in the rat brain? Br J Pharmacol. 1982 Mar;75 (3) :525-30. |[4]Erenburg N, Hamed R, Shaul C, Perucca E, Bialer M. Comparative activity of the enantiomers of fenfluramine and norfenfluramine in rodent seizure models, and relationship with their concentrations in plasma and brain. Epilepsia. 2023;64 (6) :1673-1683.