Ligustroflavone (Standard)

Ligustroflavone (Standard) is the analytical standard of Ligustroflavone (HY-N0546) . This product is intended for research and analytical applications. Ligustroflavone is an orally active flavonoid compound. Ligustroflavone can be extracted from Ligustrum lucidum. Ligustroflavone antagonizes the calcium-sensing receptor (CaSR), inhibits the RIPK1/RIPK3/MLKL pathway, and downregulates TGF-β/Smad signaling. Ligustroflavone regulates calcium metabolism, protects bone tissue, reduces cerebral ischemic injury, and inhibits liver fibrosis. Ligustroflavone can be used in the study of diabetic osteoporosis, ischemic stroke, and liver fibrosis[1][2][3].

Product Specifications

CAS Number

[260413-62-5]

Product Name Alternative

Nuezhenoside (Standard)

UNSPSC

12352005

Target

CaSR; Mixed Lineage Kinase; Reference Standards; RIP kinase; TGF-beta/Smad

Type

Reference Standards

Related Pathways

Apoptosis; GPCR/G Protein; MAPK/ERK Pathway; Others; Stem Cell/Wnt; TGF-beta/Smad

Field of Research

Endocrinology; Metabolic Disease; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ligustroflavone-standard.html

Smiles

O=C(C=C(C1=CC=C(O)C=C1)OC2=CC(O[C@H](O[C@H](CO[C@H](O[C@@H](C)[C@H](O)[C@H]3O)[C@@H]3O)[C@@H](O)[C@@H]4O)[C@@H]4O[C@@](O[C@@H](C)[C@H](O)[C@H]5O)([H])[C@@H]5O)=C6)C2=C6O

Molecular Formula

C33H40O18

Molecular Weight

724.66

References & Citations

[1]Feng R, et al. Protective Effects of Ligustroflavone, an Active Compound from Ligustrum lucidum, on Diabetes-Induced Osteoporosis in Mice: A Potential Candidate as Calcium-Sensing Receptor Antagonist. Am J Chin Med. 2019;47 (2) :457-476.