PK 11195

PK 11195 (RP 52028) is a ligand of translocator protein (TSPO), which targets Leishmania chemotherapy, with IC50s of 14.2 μM, 8.2 μM, 3.5 μM for L. amazonensis, L. major and L. braziliensis, respectively.

Product Specifications

CAS Number

[85532-75-8]

Product Name Alternative

RP 52028

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/PK-11195.html

Purity

99.91

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(N(C(CC)C)C)C1=CC2=CC=CC=C2C(C3=CC=CC=C3Cl)=N1

Molecular Formula

C21H21ClN2O

Molecular Weight

352.86

References & Citations

[1]Guedes CES, et al. In vitro evaluation of the anti-leishmanial activity and toxicity of PK-11195. Mem Inst Oswaldo Cruz. 2018 Feb 5;113 (4) :e170345.