PK 11195
PK 11195 (RP 52028) is a ligand of translocator protein (TSPO), which targets Leishmania chemotherapy, with IC50s of 14.2 μM, 8.2 μM, 3.5 μM for L. amazonensis, L. major and L. braziliensis, respectively.
Product Specifications
CAS Number
[85532-75-8]
Product Name Alternative
RP 52028
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/PK-11195.html
Purity
99.91
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(N(C(CC)C)C)C1=CC2=CC=CC=C2C(C3=CC=CC=C3Cl)=N1
Molecular Formula
C21H21ClN2O
Molecular Weight
352.86
References & Citations
[1]Guedes CES, et al. In vitro evaluation of the anti-leishmanial activity and toxicity of PK-11195. Mem Inst Oswaldo Cruz. 2018 Feb 5;113 (4) :e170345.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Leishmania
Available Sizes
Curated Selection
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