SFI003
SFI003 is a SRSF3 inhibitor that drives CRC cell apoptosis via the SRSF3/DHCR24/ROS axis and exhibits potent antitumor effects both in vitro and in vivo[1].
Product Specifications
CAS Number
2361332-90-1
UNSPSC
12352005
Target
Apoptosis; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sfi003.html
Purity
99.75
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
COC(C=C1)=CC=C1C2=CSC(N/N=C(C3=NC4=CC=CC=C4N3)\C)=N2
Molecular Formula
C19H17N5OS
Molecular Weight
363.44
References & Citations
[1]Zhang Y, et al. A novel SRSF3 inhibitor, SFI003, exerts anticancer activity against colorectal cancer by modulating the SRSF3/DHCR24/ROS axis. Cell Death Discov. 2022 May 2;8 (1) :238.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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