SFI003

SFI003 is a SRSF3 inhibitor that drives CRC cell apoptosis via the SRSF3/DHCR24/ROS axis and exhibits potent antitumor effects both in vitro and in vivo[1].

Product Specifications

CAS Number

[2361332-90-1]

UNSPSC

12352005

Target

Apoptosis; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sfi003.html

Purity

99.75

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

COC(C=C1)=CC=C1C2=CSC(N/N=C(C3=NC4=CC=CC=C4N3)\C)=N2

Molecular Formula

C19H17N5OS

Molecular Weight

363.44

References & Citations

[1]Zhang Y, et al. A novel SRSF3 inhibitor, SFI003, exerts anticancer activity against colorectal cancer by modulating the SRSF3/DHCR24/ROS axis. Cell Death Discov. 2022 May 2;8 (1) :238.