Argatroban (monohydrate)

Argatroban (monohydrate) (MD-805 (monohydrate) ) is a direct, selective thrombin inhibitor.

Product Specifications

CAS Number

[141396-28-3]

Product Name Alternative

MD-805 (monohydrate) ; MCI-9038 (monohydrate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Thrombin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Argatroban-monohydrate.html

Purity

99.57

Solubility

DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL

Smiles

O=C([C@@H]1N(C([C@@H](NS(=O)(C2=CC=CC3=C2NCC(C)C3)=O)CCCNC(N)=N)=O)CC[C@@H](C)C1)O.O

Molecular Formula

C23H38N6O6S

Molecular Weight

526.65

Precautions

H302, H315, H319, H335

References & Citations

[1]Kawada, T., et al., Argatroban, an attractive anticoagulant, for left heart bypass with centrifugal pump for repair of traumatic aortic rupture. Jpn J Thorac Cardiovasc Surg, 1999. 47 (3) : p. 104-9.|[2]Jang, I.K., et al., A multicenter, randomized study of argatroban versus heparin as adjunct to tissue plasminogen activator (TPA) in acute myocardial infarction: myocardial infarction with novastan and TPA (MINT) study. J Am Coll Cardiol, 1999. 33 (7) : p. 1879-85.|[3]Hashimoto M, et al. Suppression of argatroban-induced endogenous thrombolysis by PKSI-527, and antibodies to TPA and UPA, evaluated in a rat arterial thrombolysis model. Thromb Haemost. 2003 May;89 (5) :820-5.|[4]Lopez M, et al. Influence of renal and hepatic failure on the pharmacokinetics of argatroban: an experimental study in rats. Seminars in thrombosis and hemostasis. 2008, 34 (S 01) : 103-107.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

Antiviral Res. 2023 Jun:214:105606.|Biomed Pharmacother. 2025 Apr 28:187:118104.|Int Immunopharmacol. 2025 Apr 4:151:114334.|Int J Mol Sci. 2021 Mar 24;22 (7) :3323.|University of Bonn. 2023 May 31.