Biotin (Standard)

Biotin (Standard) is the analytical standard of Biotin. Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids[1][2][3].

Product Specifications

CAS Number

[58-85-5]

Product Name Alternative

Vitamin B7 (Standard) ; Vitamin H (Standard) ; D-Biotin (Standard)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Reference Standards

Type

Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/biotin-standard.html

Purity

98.05

Smiles

O=C(O)CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O

Molecular Formula

C10H16N2O3S

Molecular Weight

244.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Vadlapudi AD, et al. Biotin uptake by T47D breast cancer cells: functional and molecular evidence of sodium-dependent multivitamin transporter (SMVT) . Int J Pharm. 2013 Jan 30;441 (1-2) :535-43. |[2]Zempleni, et al. Biotin biochemistry and human requirements. J Nutr Biochem, 1999. 10 (3) : p. 128-38.|[3]Sghaier R, et al. Biotin attenuation of oxidative stress, mitochondrial dysfunction, lipid metabolism alteration and 7β-hydroxycholesterol-induced cell death in 158N murine oligodendrocytes. Free Radic Res. 2019 May;53 (5) :535-561. |[4]Mock, D.M.. Biotin status: which are valid indicators and how do we know? J Nutr, 1999. 129 (2S Suppl) : p. 498S-503S.|[5]Aldahmash BA, et al. Biotin amelioration of nephrotoxicity in streptozotocin-induced diabetic mice. Saudi J Biol Sci. 2015 Sep;22 (5) :564-9. |[6]Zempleni J, et al. Biotin. Biofactors. 2009 Jan-Feb;35 (1) :36-46.|[7]He P, et al. Dietary biotin deficiency decreased growth performance and impaired the immune function of the head kidney, spleen and skin in on-growing grass carp (Ctenopharyngodon idella) . Fish Shellfish Immunol. 2020 Feb;97:216-234.