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BMS-707035

BMS-707035 is a potent orally active HIV-1 integrase strand transfer inhibitor (INSTI) . BMS-707035 has enzyme inhibitory with an IC50 value of 3 nM. BMS-707035 also has weak CYP inhibiton and antiviral activity. BMS-707035 can be used for the research of human immunodeficiency virus-1 (HIV-1) [1].

Product Specifications

CAS Number

729607-74-3

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HIV; HIV Integrase

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/BMS-707035.html

Purity

99.99

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

FC1=CC=C(C=C1)CNC(C(N=C(N2C)N3S(CCCC3)(=O)=O)=C(C2=O)O)=O

Molecular Formula

C17H19FN4O5S

Molecular Weight

410.42

Precautions

H302, H315, H319, H335

References & Citations

[1]B Narasimhulu Naidu, et al. The discovery and preclinical evaluation of BMS-707035, a potent HIV-1 integrase strand transfer inhibitor. Bioorg Med Chem Lett. 2018 Jul 1;28 (12) :2124-2130.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

HIV-1

Available Sizes

Frequently Asked Questions

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