VO-Ohpic (trihydrate)
Product Specifications
UNSPSC Description
VO-Ohpic trihydrate is a highly potent inhibitor of PTEN with an IC50 of 46±10 nM.
Target Antigen
Autophagy; PTEN
Type
Reference compound
Related Pathways
Autophagy;PI3K/Akt/mTOR
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/VO-Ohpic-trihydrate.html
Purity
98.0
Solubility
DMSO : ≥ 50 mg/mL|H2O : < 0.1 mg/mL
Smiles
O=C1[O-][V+2]2([O-]C(C3=[N]2C=CC=C3O)=O)([O-]C4=CC=CN=C14)([OH2])=O.[H+].[3H2O]
Molecular Weight
415.20
References & Citations
[1]Mak LH, et al. Characterisation of the PTEN inhibitor VO-OHpic.
 J Chem Biol. 2010 Oct;3(4):157-63.|[2]Rosivatz, E, et al. A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem Biol. 2006 Dec 15;1(12):780-90.|[3]Zu L, et al. PTEN inhibitors cause a negative inotropic and chronotropic effect in mice.
 Eur J Pharmacol. 2011 Jan 10;650(1):298-302.Biochem Pharmacol. 2020 Jan;171:113715.|Biochem Pharmacol. 2019 Oct;168:82-90. |Biochim Biophys Acta Mol Basis Dis. 2022 Jan 1;1868(1):166292.|Biochim Biophys Acta Mol Basis Dis. 25 October 2021, 166292.|BMC Cancer. 2019 Apr 25;19(1):391.|Bone Res. 2018 Nov 10;6:32.|Cancer Med. 2019 Aug;8(9):4265-4277.|Cell Death Dis. 2019 May; 10(5): 329.|Cell Stem Cell. 2022 Apr 7;29(4):545-558.e13.|Clin Transl Med. 2020 Dec;10(8):e240.|Clin Transl Med. 2022 Sep;12(9):e1061.|Environ Sci Technol. 2020 Sep 1;54(17):10783-10796.|Eur Rev Med Pharmacol Sci. 2019 May;23(10):4406-4413.|Funct Integr Genomics. 2024 Apr 3;24(2):71.|Int Immunopharmacol. 2021 Dec 23;103:107840.|Int J Mol Med. 2021 Apr 19.|Int J Mol Sci. 2023 Jun 9, 24(12), 9954.|iScience. 2024 June 19.|J Adv Res. 2024 Sep 29:S2090-1232(24)00429-6.|J Cell Mol Med. 2019 Nov;23(11):7535-7544.|Mol Med Rep. 2018 Dec;18(6):5489-5501.|Mol Med Rep. 2022 Jul;26(1):246.|Mol Nutr Food Res. 2019 Dec;63(24):e1900418.|Mol Vis. 2018 Jul 23;24:485-494.|Redox Biol. 2019 Jan;20:390-401. |Redox Biol. 2024 May 17:73:103200.|Stem Cell Res Ther. 2019 Jul 29;10(1):217.|Theranostics. 2019 Jul 9;9(16):4764-4778.|Theranostics. 2019 Jul 9;9(18):5200-5213.|Transl Psychiatry. 2021 Mar 26;11(1):185.|Phytomedicine. 2023 Sep 22, 155117.|SSRN. 2023 Jul 17.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-13074/VO-Ohpic-trihydrate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13074/VO-Ohpic-trihydrate-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
476310-60-8
Available Sizes
Curated Selection
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