2'-O-Methyl-5-iodouridine
2’-O-Methyl-5-iodouridine (5-Iodo-2'-O-methyluridine) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Product Specifications
CAS Number
[34218-84-3]
Product Name Alternative
5-Iodo-2'-O-methyluridine
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Apoptosis; DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/2-o-methyl-5-iodouridine.html
Solubility
10 mM in DMSO
Smiles
O[C@H]1[C@@H](OC)[C@H](N2C(NC(C(I)=C2)=O)=O)O[C@@H]1CO
Molecular Formula
C10H13IN2O6
Molecular Weight
384.12
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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