Tivantinib

Tivantinib is a highly selective c-Met tyrosine kinase inhibitor with a Ki of 355 nM.

Product Specifications

CAS Number

[905854-02-6]

Product Name Alternative

ARQ 197; (3R,4R) -ARQ 198

UNSPSC

12352005

Hazard Statement

H360, H373

Target

Apoptosis; c-Met/HGFR

Type

Reference compound

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Tivantinib.html

Purity

99.61

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1=O)[C@@H](C2=CN3C4=C(C=CC=C42)CCC3)[C@@H]1C5=CNC6=C5C=CC=C6

Molecular Formula

C23H19N3O2

Molecular Weight

369.42

Precautions

H360, H373

References & Citations

[1]Munshi N, et al. ARQ 197, a novel and selective inhibitor of the human c-Met receptor tyrosine kinase with antitumor activity. Mol Cancer Ther. 2010 Jun;9 (6) :1544-53.|[2]Bai YL, et al. Quantitative analysis of tivantinib in rat plasma using ultra performance liquid chromatography with tandem mass spectrometry. J Pharm Biomed Anal. 2016 Jul 15;126:98-102.