AGL-2263
AGL-2263 is an insulin receptor and insulin-like growth factor (IGF) receptor inhibitor[1][2].
Product Specifications
CAS Number
638213-98-6
UNSPSC
12352005
Target
Insulin Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/AGL-2263.html
Purity
98.31
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(O)=C(O)C=C1)/C(C#N)=C/C2=CC=C(OC3=O)C(N3)=C2
Molecular Formula
C17H10N2O5
Molecular Weight
322.27
References & Citations
[1]Li Y, et al. GDM-associated insulin deficiency hinders the dissociation of SERT from ERp44 and down-regulates placental 5-HT uptake. Proc Natl Acad Sci U S A. 2014 Dec 30;111 (52) :E5697-705.|[2]Hua Zhang, et al. Somatic cells initiate primordial follicle activation and govern the development of dormant oocytes in mice. Curr Biol. 2014 Nov 3;24 (21) :2501-8.|[3]Ying Han, et al. Insulin mitigates apoptosis of porcine follicular granulosa cells by downregulating BimEL. Reprod Biol. 2019 Sep;19 (3) :293-298.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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