L-5-Hydroxytryptophan

L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist[1]. L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia[2][3][4][5].

Product Specifications

CAS Number

[4350-09-8]

Product Name Alternative

L-5-HTP; Oxitriptan

UNSPSC

12352005

Hazard Statement

H301

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/L-5-Hydroxytryptophan.html

Purity

99.99

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 14 mg/mL (ultrasonic)

Smiles

N[C@@H](CC1=CNC2=CC=C(O)C=C12)C(O)=O

Molecular Formula

C11H12N2O3

Molecular Weight

220.23

Precautions

H301

References & Citations

[1]ARVID CARLSSON, et al. 3,4-Dihydroxyphenylalanine and 5-Hydroxytryptophan as Reserpine Antagonists. Nature 180, page1200 (1957) .|[2]Caruso I, et al. Double-blind study of 5-hydroxytryptophan versus placebo in the treatment of primary fibromyalgia syndrome. J Int Med Res. 1990 May-Jun;18 (3) :201-9.|[3]Thal LJ, et al. Treatment of myoclonus with L-5-hydroxytryptophan and carbidopa: clinical, electrophysiological, and biochemical observations. Ann Neurol. 1980 Jun;7 (6) :570-6.|[4]Boiardi A, et al. 5-OH-Tryptophane in migraine: clinical and neurophysiological considerations. J Neurol. 1981;225 (1) :41-6.|[5]Trouillas P, et al. Improvement of cerebellar ataxia with levorotatory form of 5-hydroxytryptophan. A double-blind study with quantified data processing. Arch Neurol. 1988 Nov;45 (11) :1217-22.