Thiamine pyrophosphate

Thiamine pyrophosphate is the coenzyme form of Vitamin B1, and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex. Thiamine pyrophosphate is necessary for oxidative phosphorylation and the pentose phosphate pathway by acting as a cofactor for α-ketoacid dehydrogenases[1][2][3].

Product Specifications

CAS Number

[154-87-0]

Product Name Alternative

Cocarboxylase

UNSPSC

12352005

Hazard Statement

H317

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Thiamine_pyrophosphate.html

Purity

99.93

Solubility

DMSO : < 1 mg/mL (ultrasonic) |H2O : 41.67 mg/mL (ultrasonic)

Smiles

OP(OP(OCCC1=C(C)[N+](CC2=CN=C(C)N=C2N)=CS1)(O)=O)(O)=O.[Cl-]

Molecular Formula

C12H19ClN4O7P2S

Molecular Weight

460.77

Precautions

H317

References & Citations

[1]Demiryilmaz I, et al. A comparative investigation of biochemical and histopathological effects of thiamine and thiamine pyrophosphate on ischemia-reperfusion induced oxidative damage in rat ovarian tissue. Arch Pharm Res. 2013 Sep;36 (9) :1133-9.|[2]Coskun R, et al. The protective effect of thiamine pyrophosphate, but not thiamine, against cardiotoxicity induced with cisplatin in rats. Drug Chem Toxicol. 2014 Jul;37 (3) :290-4.|[3]de Jong L, et al. Thiamine pyrophosphate biosynthesis and transport in the nematode Caenorhabditis elegans. Genetics. 2004 Oct;168 (2) :845-54.