N-Acetylcysteine amide

N-Acetylcysteine amide is a cell membranes and blood brain barrier permeant thiol antioxidant and neuroprotective agent, reduces ROS production.

Product Specifications

CAS Number

[38520-57-9]

UNSPSC

12352211

Hazard Statement

H302

Target

Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/N-Acetylcysteine_amide.html

Purity

99.88

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CC(N[C@@H](CS)C(N)=O)=O

Molecular Formula

C5H10N2O2S

Molecular Weight

162.21

Precautions

H302

References & Citations

[1]Shi R, et al. N-acetylcysteine amide decreases oxidative stress but not cell death induced by doxorubicin in H9c2 cardiomyocytes. BMC Pharmacol. 2009 Apr 15;9:7.|[2]Pandya JD, et al. N-acetylcysteine amide confers neuroprotection, improves bioenergetics and behavioral outcome following TBI. Exp Neurol. 2014 Jul;257:106-13.|[3]Zhang X, et al. N-Acetylcysteine amide protects against methamphetamine-induced oxidative stress and neurotoxicity in immortalized human brain endothelial cells. Brain Res. 2009 Jun 12;1275:87-95.