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Lisaftoclax

Product Specifications

Product Name Alternative

APG-2575; Bcl-2/Bcl-xl inhibitor 1

UNSPSC Description

Lisaftoclax (compound 6) is a dual Bcl-2 and Bcl-xl inhibitor with anti-tumor activity, extracted from patent WO2018027097A1. Lisaftoclax exhibits IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively[1].

Target Antigen

Bcl-2 Family

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bcl-2-bcl-xl-inhibitor-1.html

Purity

99.28

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NS(=O)(C1=CC=C(NC[C@@H]2OCCOC2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4CCN(CC(CC5)=C(C6=CC=C(Cl)C=C6)CC75CCC7)CC4)C=C3OC8=CN=C(NC=C9)C9=C8

Molecular Weight

882.42

References & Citations

[1]WANG, Chia, et al. N-(PHENYLSULFONYL)BENZAMIDES AND RELATED COMPOUNDS AS BCL-2 INHIBITORS. Patent. WO2018027097A1.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-129179/Lisaftoclax-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-129179/Lisaftoclax-SDS-MedChemExpress.pdf

Clinical Information

Phase 3

CAS Number

2180923-05-9

Available Sizes

Curated Selection

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