Acacetin

Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an orally active flavonoid derived from Dendranthema morifolium. Acacetin docks in the ATP binding pocket of PI3Kγ. Acacetin causes cell cycle arrest and induces apoptosis and autophagy in cancer cells. Acacetin has potent anti-cancer and anti-inflammatory activity and has the potential for pain-related diseases research[1][2].

Product Specifications

CAS Number

[480-44-4]

Product Name Alternative

5,7-Dihydroxy-4'-methoxyflavone

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis; Autophagy

Type

Natural Products

Related Pathways

Apoptosis; Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Acacetin.html

Concentration

10mM

Purity

99.71

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1C=C(C2=CC=C(OC)C=C2)OC3=CC(O)=CC(O)=C13

Molecular Formula

C16H12O5

Molecular Weight

284.26

Precautions

H315, H319, H335

References & Citations

[1]Hong-Wei Zhang, et al. Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kγ mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells. Sci Rep. 2018 Jul 26;8 (1) :11255.|[2]Sang Keun Ha, et al. Acacetin attenuates neuroinflammation via regulation the response to LPS stimuli in vitro and in vivo. Neurochem Res. 2012 Jul;37 (7) :1560-7.|[3]A I Carballo-Villalobos, et al. Evidence of mechanism of action of anti-inflammatory/antinociceptive activities of acacetin. Eur J Pain. 2014 Mar;18 (3) :396-405.