MI-538
MI-538 is an inhibitor of the interaction between menin and MLL fusion proteins with an IC50 of 21 nM.
Product Specifications
CAS Number
1857417-10-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/MI-538.html
Concentration
10mM
Purity
98.23
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(F)(F)CC(S1)=CC2=C1N=CN=C2NC3CCN(CC4=C(O)C=C(N(CC5=CNN=C5)C(C#N)=C6)C6=C4)CC3
Molecular Formula
C27H25F3N8OS
Molecular Weight
566.60
Precautions
H302, H315, H319, H335
References & Citations
[1]Borkin D, et al. Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL) . J Med Chem. 2016 Feb 11;59 (3) :892-913.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TL301231V 500 µL Each
TAS2R41 Human shRNA Lentiviral Particle (Locus ID 259287)
Sign In for Pricing
View Details 
MBS6458797-01 0.1 mL
RLF (Zinc Finger Protein Rlf, Rearranged L-myc fusion gene Protein, Zn-15-Related Protein, RLF) (MaxLight 490)
Sign In for Pricing
View Details MBS6458797-02 5x 0.1 mL
RLF (Zinc Finger Protein Rlf, Rearranged L-myc fusion gene Protein, Zn-15-Related Protein, RLF) (MaxLight 490)
Sign In for Pricing
View Details orb1377988 20 µg
Nuclear Matrix Protein p84 (THOC1) Human Over-expression Lysate
Sign In for Pricing
View Details