Mc-Val-Cit-PABC-PNP
Product Specifications
UNSPSC Description
Mc-Val-Cit-PABC-PNP is a cathepsin cleavable linker for antibody-drug conjugates (ADCs) which couples the antibody element to the effecting compound. Mc-Val-Cit-PABC-PNP can be used in the synthesis of ADCs[1][2].
Target Antigen
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology; Others
Assay Protocol
https://www.medchemexpress.com/Mc-Val-Cit-PABC-PNP.html
Purity
98.89
Solubility
DMSO : ≥ 37 mg/mL
Smiles
CC(C)[C@@H](C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(COC(OC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1)=O)=O)NC(CCCCCN3C(C=CC3=O)=O)=O
Molecular Weight
737.76
References & Citations
[1]Che-Leung Law et al. Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders.Patent WO2005081711A2.|[2]Li Y, et al. Discovery of novel antibody-drug conjugates bearing tissue protease specific linker with both anti-angiogenic and strong cytotoxic effects. Bioorg Chem. 2023 Aug;137:106575.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-20336/Mc-Val-Cit-PABC-PNP-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-20336/Mc-Val-Cit-PABC-PNP-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
159857-81-5
Available Sizes
Curated Selection
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