SCH-900271
SCH-900271 is an orally active, potent nicotinic acid receptor (NAR) agonist with an EC50 of 2 nM in the hu-GPR109a assay. SCH-900271 exhibits dose-dependent inhibition of plasma free fatty acid (FFA) . SCH-900271 has an improved therapeutic window to flushing[1].
Product Specifications
CAS Number
[915210-50-3]
UNSPSC
12352005
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/sch-900271.html
Purity
98.64
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1NC2=C(C(CCCC3(C)CC3)=CC(O2)=O)C(N1)=O
Molecular Formula
C14H16N2O4
Molecular Weight
276.29
References & Citations
[1]Anandan Palani, et al. Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia. ACS Med Chem Lett. 2011 Nov 24;3 (1) :63-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Curated Selection
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