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Ocifisertib (fumarate)

Product Specifications

Product Name Alternative

CFI-400945 (fumarate)

UNSPSC Description

CFI-400945 fumarate is a potent, selective and orally bioavailable PLK4 inhibitor with a Ki and an IC50 of 0.26 nM and 2.8 nM, respectively.

Target Antigen

Polo-like Kinase (PLK)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cc_fumarate_.html

Purity

99.44

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC(/C=C/C(O)=O)=O.O=C1[C@@]2(C3=CC(OC)=CC=C3N1)[C@H](C4=CC=C(C(/C=C/C5=CC=C(C=C5)CN6C[C@H](O[C@H](C6)C)C)=NN7)C7=C4)C2

Molecular Weight

650.72

References & Citations

[1]Sampson PB, et al. The discovery of Polo-like kinase 4 inhibitors: identification of (1R,2S).2-(3-((E).4-(((cis).2,6-dimethylmorpholino)methyl)styryl). 1H.indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one (CFI-400945) as a potent, orally active antitumor agent. J Med Chem. 2015 Jan 8;58(1):147-69.|[2]Mason JM, et al. Functional characterization of CFI-400945, a Polo-like kinase 4 inhibitor, as a potential anticancer agent. Cancer Cell. 2014 Aug 11;26(2):163-76.Int J Mol Med. 2021 Jan;47(1):151-160.|Ir J Med Sci. 2022 May 4.|J Cancer Res Clin Oncol. 2020 Nov;146(11):2871-2883.|Nat Nanotechnol. 2021 Jul;16(7):830-839.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-12300B/Ocifisertib-fumarate-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-12300B/Ocifisertib-fumarate-SDS-MedChemExpress.pdf

Clinical Information

Phase 2

CAS Number

1616420-30-4

Available Sizes

Curated Selection

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