DR4485 (hydrochloride)

DR4485 (hydrochloride) is an orally active and selective 5-HT7 antagonist (pKi=8.14) [1].

Product Specifications

CAS Number

[402942-53-4]

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dr4485-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C1NC2=C3C1(CCCCN4CC=C(C5=CC=C(Cl)C=C5)CC4)CCCC3=C(Cl)C=C2.[H]Cl

Molecular Formula

C26H29Cl3N2O

Molecular Weight

491.88

References & Citations

[1]Kikuchi C, et al. New tetrahydrobenzindoles as potent and selective 5-HT (7) antagonists with increased In vitro metabolic stability. Bioorg Med Chem Lett. 2003;13 (1) :61-64.|[2]Meyer N, et al. Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death [published online ahead of print, 2021 Jan 19]. Autophagy. 2021;1-20.