DR4485 (hydrochloride)
DR4485 (hydrochloride) is an orally active and selective 5-HT7 antagonist (pKi=8.14) [1].
Product Specifications
CAS Number
402942-53-4
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dr4485-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C1NC2=C3C1(CCCCN4CC=C(C5=CC=C(Cl)C=C5)CC4)CCCC3=C(Cl)C=C2.[H]Cl
Molecular Formula
C26H29Cl3N2O
Molecular Weight
491.88
References & Citations
[1]Kikuchi C, et al. New tetrahydrobenzindoles as potent and selective 5-HT (7) antagonists with increased In vitro metabolic stability. Bioorg Med Chem Lett. 2003;13 (1) :61-64.|[2]Meyer N, et al. Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death [published online ahead of print, 2021 Jan 19]. Autophagy. 2021;1-20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT7 Receptor; MUC3
Available Sizes
Frequently Asked Questions
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