Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

AGN 196996

AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ (Ki=1087 nM) and RARγ (Ki=8523 nM) . IC50 value: 2 nM (Ki) Target: RARα antagonist AGN 196996 shows no activity in transactivation assays, but instead block the gene transcriptional activity induced by ATRA and other RAR agonists.

Product Specifications

CAS Number

958295-17-5

UNSPSC

12352005

Target

Autophagy; RAR/RXR

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/AGN-196996.html

Purity

99.76

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

BrC1=CC(C(NC2=CC=C(C(O)=O)C=C2)=O)=CC(C(C3=CC=C(C)C=C3)=O)=C1OCC

Molecular Formula

C24H20BrNO5

Molecular Weight

482.32

References & Citations

[1]Hammond LA, et al. Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells. Br J Cancer. 2001 Aug 3;85 (3) :453-62.|[2]Keedwell RG, et al. An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium. Br J Cancer. 2004 Aug 2;91 (3) :580-8.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Sval2 Mouse Gene Knockout Kit (CRISPR)
KN517015 1 Kit

Sval2 Mouse Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
SPANXB1 Mouse Monoclonal Antibody [Clone ID: OTI6G2]
CF811401 100 µg

SPANXB1 Mouse Monoclonal Antibody [Clone ID: OTI6G2]

Sign In for Pricing
View Details
PDE6 gamma (PDE6G) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1H7]
TA503705AM 100 µL

PDE6 gamma (PDE6G) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1H7]

Sign In for Pricing
View Details
rac Viloxazine-d5 Hydrochloride
TRC-V312442-1MG 1 mg

rac Viloxazine-d5 Hydrochloride

Sign In for Pricing
View Details
RhoGDI (ARHGDIA) (C-term) Rabbit Polyclonal Antibody
AP17127PU-N 400 µL

RhoGDI (ARHGDIA) (C-term) Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
Carcino Embryonic Antigen CEA (CD66e) Antibody
KC-6053-01 50 μL

Carcino Embryonic Antigen CEA (CD66e) Antibody

Sign In for Pricing
View Details