SC-560

SC-560 is a potent and selective COX-1 inhibitor with an IC50 of 9 nM.

Product Specifications

CAS Number

[188817-13-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/SC-560.html

Concentration

10mM

Purity

99.79

Solubility

DMSO : ≥ 100 mg/mL

Smiles

FC(C1=NN(C2=CC=C(OC)C=C2)C(C3=CC=C(Cl)C=C3)=C1)(F)F

Molecular Formula

C17H12ClF3N2O

Molecular Weight

352.74

Precautions

H302, H315, H319, H335

References & Citations

[1]Smith CJ, et al. Pharmacological analysis of cyclooxygenase-1 in inflammation. Proc Natl Acad Sci U S A. 1998 Oct 27;95 (22) :13313-8.|[2]Lampiasi N, et al. The selective cyclooxygenase-1 inhibitor SC-560 suppresses cell proliferation and induces apoptosis in human hepatocellular carcinoma cells. Int J Mol Med. 2006 Feb;17 (2) :245-52.|[3]Teng XW, et al. Formulation dependent pharmacokinetics, bioavailability and renal toxicity of a selective cyclooxygenase-1 inhibitor SC-560 in the rat. J Pharm Pharm Sci. 2003 May-Aug;6 (2) :205-10.