AS-252424
AS-252424 is a potent and selective PI3Kγ inhibitor with an IC50 of 30±10 nM.
Product Specifications
CAS Number
[900515-16-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AS-252424.html
Concentration
10mM
Purity
99.66
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(NC/1=O)SC1=C/C2=CC=C(C3=CC=C(F)C=C3O)O2
Molecular Formula
C14H8FNO4S
Molecular Weight
305.28
Precautions
H302, H315, H319
References & Citations
[1]Pomel V, et al. Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma. J Med Chem. 2006 Jun 29;49 (13) :3857-71.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
Available Sizes
Curated Selection
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