Conduritol B epoxide

Conduritol B epoxide is an irreversible covalently bound acid β-glucosidase (GCase) inhibitor.

Product Specifications

CAS Number

[6090-95-5]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Glycosidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Conduritol-B-epoxide.html

Purity

99.92

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H]2[C@@H]1O2

Molecular Formula

C6H10O5

Molecular Weight

162.14

Precautions

H315, H319, H335

References & Citations

[1]Liou B, et al. Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice. Hum Mol Genet. 2016 Sep 20. pii: ddw322. [Epub ahead of print]|[2]YH Xu, et al. Accumulation and distribution of α-synuclein and ubiquitin in the CNS of Gaucher disease mouse models. Mol Genet Metab. Author manuscript; available in PMC 2012 Apr 1