AJG049 (free base)
AJG049 free base is a calcium channel (Ca2+ channel) antagonist. AJG049 free base regulates vascular relaxation, reduces cardiac load, and improves cardiac perfusion by binding to the binding site of L-type calcium channels, specifically Diltiazem. AJG049 free base can be used in cardiovascular disease research[1].
Product Specifications
CAS Number
195991-49-2
UNSPSC
12352005
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ajg049-free-base.html
Smiles
COC(C=C1)=CC=C1CCN(CCC2)[C@H]2CN3C4=CC=CC=C4COC5=CC=CC=C53
Molecular Formula
C27H30N2O2
Molecular Weight
414.54
References & Citations
[1]Hashimoto M, et al. Comparative studies of AJG049, a novel Ca2+ channel antagonist, on voltage-dependent L-type Ca2+ currents in intestinal and vascular smooth muscle. Br J Pharmacol. 2006 Sep;149 (2) :155-62.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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