Recombinant Human Cu/Zn Superoxide Dismutase Homodimer
Recombinant Human Cu/Zn Superoxide Dismutase Homodimer
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
SOD1
Gene Name
SOD1
UniProt
P00441
Cellular Locus
Cytoplasm , Mitochondrion , Nucleus , Note=Predominantly cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria.
Reactivity
Human
Target Antigen
Superoxide dismutase [Cu-Zn]
Target
Cu/Zn Superoxide Dismutase Homodimer
Type
Protein
Applications
WB
Dilution
Reconstitute lyophilized product in sterile distilled H2O to no less than 100ug/ml which can be further diluted in other aqueous solutions as needed.
Form
Lyophilized
Buffer
PBS
Function
Destroys radicals which are normally produced within the cells and which are toxic to biological systems. {PubMed:24140062}.
Storage Conditions
Although lyophilized product is stable at room temperature for 3 weeks, it is best stored at or below -20°C. After reconstitution, product should be stored at or below -20°C. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage.
Specificity
Cu/Zn Superoxide Dismutase Homodimer
Formulation
Lyophilized from a sterile-filtered solution (1mg/ml) in PBS, pH 7.4
Buffer pH
pH 7.4
Target Background
Cu/Zn Superoxide Dismutase (SOD1) catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. It protects a cell from dangerous levels of superoxide. SOD1 binds copper and zinc ions and is one of three isozymes responsible for destroying free superoxide radicals. Mutations in SOD1 cause a form of familial amyotrophic lateral sclerosis (ALS).
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