MNK8

MNK8 is a potent STAT3 (signal transducer and activator of transcription 3) inhibitor. MNK8 inhibits STAT3 activation and reduced its DNA binding ability. MNK8 shows good growth inhibition against hepatocellular carcinoma (HCC) cells. MNK8 induces apoptosis in HCC cells. MNK8 reduces prosurvival proteins expression and migration/invasion of HCC cells[1].

Product Specifications

CAS Number

[2055078-49-2]

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family; STAT; Survivin

Type

Reference compound

Related Pathways

Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mnk8.html

Purity

99.76

Solubility

DMSO : 41.67 mg/mL (ultrasonic)

Smiles

O=C1N(C)C(C=C(C2=C3C=CC=CC3=CC=C2)N1)=O

Molecular Formula

C15H12N2O2

Molecular Weight

252.27

References & Citations

[1]Sajith AM, et al. Pyrimidine-2,4-dione targets STAT3 signaling pathway to induce cytotoxicity in hepatocellular carcinoma cells. Bioorg Med Chem Lett. 2021 Oct 15;50:128332.