RP-2119
RP-2119 (Compound 113) is an orally active inhibitor of Polymerase Theta (Polθ) . RP-2119 has antitumor activity[1].
Product Specifications
CAS Number
2922287-81-6
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/polθ-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C=C(N=C1)C2=NN(C=C2)C)C3=CC(C(F)F)=NC=C3OC)NC4=NN=C(S4)C#CC5CC5
Molecular Formula
C24H19F2N7O2S
Molecular Weight
507.52
References & Citations
[1]Bingcan Liu, et al. N- (5-substituted-[ (l,3,4-thiadiazolyl) or (l,3-thiazolyl) ] (substituted) carboxamide compounds, pharmaceutical compositions, and methods of preparing the amide compounds and of their use. WO2024069592A1. 2024.04.04.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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