Nampt-IN-1
Nampt-IN-1 (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM.
Product Specifications
CAS Number
[1698878-14-6]
Product Name Alternative
LSN3154567
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
NAMPT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Nampt-IN-1.html
Purity
99.48
Solubility
DMSO : 175 mg/mL (ultrasonic)
Smiles
O=C(N1CCC(C=C(NS(CC(C)(C)O)(=O)=O)C=C2)=C2C1)COC3=CN=CC=C3
Molecular Formula
C20H25N3O5S
Molecular Weight
419.49
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhao G, et al. Discovery of a Highly Selective NAMPT Inhibitor That Demonstrates Robust Efficacy and Improved Retinal Toxicity with Nicotinic Acid Coadministration. Mol Cancer Ther. 2017 Dec;16 (12) :2677-2688.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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